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. 2020 Dec 15;11:595672. doi: 10.3389/fimmu.2020.595672

Figure 6.

Figure 6

Localization and expression of lymphorganogenic chemokines in PCC. (A–D) Colocalization (arrows) of CCL8 with vimentin and B200+ B cells in PCC near the blood vessel (thick arrow) of MRL and LPR mice at 3 and 6 months of age (IF stain). (E–H) Colocalization (arrows) of CXCL9 with vimentin and B200+ B cells in PCC near the blood vessel (thick arrow) of MRL and LPR mice at 3 and 6 months of age (IF stain). (I–L) Colocalization (arrows) of CXCL13 with vimentin and B200+ B cells in PCC near the blood vessel (thick arrow) of MRL and LPR mice at 3 and 6 months of age (IF stain). (M–P) Expression (arrows) of Ccl8 in PCC near the blood vessel (thick arrow) of MRL and LPR mice at 3 and 6 months of age (ISH). (Q–T) Expression (arrows) of Cxcl9 in PCC near the blood vessel (thick arrow) of MRL and LPR mice at 3 and 6 months of age (ISH). (U–X). Expression of Cxcl13 in PCC near the blood vessel (thick arrow) of MRL and LPR mice at 3 and 6 months of age (ISH). Bars = 100 µm. PCC, perivascular cellular cluster; IF, immunofluorescence; ISH, in situ hybridization.