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. 2020 Dec 15;11:595672. doi: 10.3389/fimmu.2020.595672

Figure 7.

Figure 7

Lymphorganogenic chemokine localization and expression in vascular and perivascular structure. (A–C) CXCL13 (arrow) did not colocalize with SMA+ smooth muscle cells of the arteries in MRL mice at 6 months of age (IF stain). (D–F) CXCL13 (arrow) colocalized (arrowhead) with SMA+ smooth muscle cell of the artery in LPR mice at 6 months of age (IF stain). (G, H) Cxcl13 was not expressed at the arterial wall of MRL mice (G) at 6 months of age but was expressed at the arterial wall of LPR mice at the same age (H) (ISH). (I) Transcripts for different genes of collagen in MRL and LPR mice at 6 months of age. Microarray analysis, significant difference from the control is indicated by * (*P < 0.05, **P < 01, 2-tailed Student’s t test). n = 3. (J) Colocalization of CXCL13 (arrow) with collagen fiber in PCC of LPR mice at 6 months of age (IHC and aniline blue stain). Bars = 100 µm. PCC, perivascular cellular cluster; IF, immunofluorescence; ISH, in situ hybridization; IHC, immunohistochemistry.