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. 2020 Dec 15;11:595672. doi: 10.3389/fimmu.2020.595672

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Copyright © 2020 Masum, Ichii, Elewa, Otani, Namba and Kon

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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VALT shows lymphoid follicular and germinal center activity. (A) Different gene transcripts related to lymphoid follicular and germinal center activity in MRL and LPR mice at 6 months of age. Microarray analysis, significant difference from the control is indicated by * (*P < 0.05, **P < 01, 2-tailed Student’s t test). n = 3. (B) CD21⁺ follicular dendritic cells (arrows) in VALT of LPR mice at 6 months of age (IHC). (C) CD138⁺ plasma cells (arrows) in VALT of LPR mice at 6 months of age (IHC). (D) IgM⁺ cells (arrows) in VALT of LPR mice at 6 months of age (IHC). (E) IgG⁺ cells (arrows) in VALT of LPR mice at 6 months of age (IHC). Bars = 100 µm. VALT, vasculature-associated lymphoid tissue; IHC, immunohistochemistry.