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. 2020 Dec 15;10:574383. doi: 10.3389/fonc.2020.574383

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Copyright © 2020 Zhu, Wu, Niu, Yao, Xue, Wang, Yang, Li and Fan

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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SAPCD2 promotes proliferation and anoikis resistance via inactivates Hippo signaling pathway in fibrosarcoma cells. (A) YAP1-S127A reversed the TEAD transcriptional activity repressed by downregulation of SAPCD2 assessed by HOP-Flash luciferase reporter. Each bar represents the mean values ± SD of three independent experiments. *P < 0.05. (B, C) YAP1-S127A reversed the inhibitory effects of SAPCD2 downregulation on colony-forming ability (B) and anchorage-independent growth capability (C) in fibrosarcoma cells. Each bar represents the mean values ± SD of three independent experiments. *P < 0.05. (D) YAP1-S127A reversed the pro-apoptotic role of SAPCD2 downregulation on in fibrosarcoma cells. Each bar represents the mean values ± SD of three independent experiments. *P < 0.05.