Table 3.
Data obtained from the radioligand displacement assay in the hippocampus and temporal neocortex of autopsies and patients with drug resistance mesial lobe epilepsy.
| Brain structure | Group | IC50 (μM) | Ki (μM) | pKi | Hill coefficient |
|---|---|---|---|---|---|
| Hippocampus | Autopsies | 129.40 ± 9.40 | 51.31 ± 3.73 | 4.29 ± 0.03 | 3.37 ± 0.27 |
| Patients | 93.61 ± 18.25 | 37.12 ± 7.24 | 4.47 ± 0.09 | 4.84 ± 0.35* | |
| Temporal neocortex | Autopsies | 54.34 ± 3.66 | 21.55 ± 1.45 | 4.67 ± 0.03 | 4.67 ± 0.93 |
| Patients | 46.84 ± 6.30 | 18.57 ± 2.50 | 4.74 ± 0.05 | 3.18 ± 0.57 |
IC50, inhibitory concentration 50; Ki, inhibition constant; pKi, inverse logarithm of Ki. Ki was determined from IC50 according to the Cheng–Prusoff equation (1973): Ki = IC50/(1 + [radioligand]/KD). Values are expressed as the mean ± SEM of five experiments. *p < 0.05 vs. autopsies.