Table 7.
Orphan products-based liposomes designated and/or approved by FDA, US Food and Drug Administration. https://www.fda.gov/(accessed on 30/04/2020).
| Generic name | Trade name | Designated indication | Marketing approved indication | Sponsor |
|---|---|---|---|---|
| Doxorubicin HCL liposome injection | Doxil | Multiple myeloma | Patients with multiple myeloma. | Johnson and Johnson Pharmaceutical Research and Dev. |
| Amphotericin B lipid complex | Abelcet | Invasive fungal infections. | Patients intolerant to conventional amphotericin B therapy. | Liposome Company, Inc. |
| Liposomal amphotericin B | AmBisome | Cryptococcal meningitis. | Treatment of cryptococcos | Bristol-Myers Squibb Pharmaceutical Research Institute |
| Liposomal amphotericin B | AmBisome | Visceral leishmaniasis. | Treatment of visceral leishmaniasis. | Fujisawa USA, Inc. |
| Daunorubicin citrate liposome injection | DaunoXome | HIV-associated Kaposi's sarcoma. | Advanced, HIV related Kaposi's sarcoma. | NeXstar Pharmaceuticals, Inc |
| Antihemophilic factor with liposome diluent | Kogenate(r) FS | Hemophilia A | N/A | Bayer HealthCare LLC |
| Cytarabine liposome | DepoCyt | Gliomas | N/A | Bruce Frankel, MD |
| Cytarabine: daunorubicin liposome injection | N/A | Myeloid leukemia | N/A | Celator Pharmaceuticals, Inc. |
| Gentamicin liposome injection | Maitec | Mycobacterium avium-intracellulare infection. | N/A | Liposome Company, Inc. |
| Liposomal nystatin | Nyotran | Invasive fungal infections. | N/A | The University of Texas |
| Cisplatin in liposomal formulation | SLIT Cisplatin for inhalation | Osteogenic sarcoma metastatic to the lung | N/A | Transave, Inc. |
| Doxorubicin liposome | Doxil | Ovarian cancer | Refractory disease to paclitaxel- and platinum | Alza Corporation |
| Cytarabine liposomal | DepoCyt | Neoplastic meningitis | Intrathecal treatment of lymphomatous meningitis | Pacira Pharmaceuticals, Inc. |
| Adeno-associated vector lipoprotein lipase protein | N/A | Lipoprotein lipase deficiency | N/A | Amsterdam Molecular Therapeutics BV |
| Amphotericin B lipid complex | Abelcet | Invasive protothecosis, sporotrichosis, coccidioidomycosis, zygomycosis and candidiasis | N/A | The Liposome Company, Inc. |
| GNE Lipoplex | N/A | Hereditary inclusion body myopathy-2 | N/A | Gradalis, Inc. |
| HLA-B7/Beta2M DNA Lipid (DMRIE/DOPE) Complex | Allovectin-7 | Metastatic melanoma (Stages II, III, and IV). | N/A | Vical Incorporated |
| Liposomal cisplatin | LipOva-Pt | Ovarian cancer | N/A | Transave, Inc. |
| Liposomal cyclosporin A | Liposomal cyclosporin A | Lung allograft and pulmonary rejection | N/A | Vernon Knight, M.D. |
| Liposomal N-Acetylglucosminyl-N-Acetylmuramly-L-Ala-D-isoGln-L-Ala -gylcerolidpalmitoyl | ImmTher | Osteosarcoma Ewing's sarcoma | N/A | Endorex Corp. |
| Liposome encapsulated recombinant interleukin-2 | N/A | Brain and central nervous system (CNS) tumors. Cancers of kidney and renal pelvis | N/A | Oncothyreon Canada, Inc |
| Liposomal-cis-bis-neodecanoato-trans-R, R-1,2-diaminocyclohexane-Pt (II) | Aroplatin | Malignant mesothelioma. | N/A | Antigenics Incorporated |
| Bupivacaine liposome injectable suspension | Exparel | Nerve Block for Regional Analgesia | N/A | PaciraPharmaceuticals, Inc. |