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Development and validation of the non-accumulating haloperidol (HAL) analog HAL-F with preserved dopamine D2 receptor affinity: (a) chemical structure of HAL-F; (b) ligand receptor interactions of HAL (green) and HAL-F (orange) with the dopamine D2 receptor (blue). HAL-F binds to dopamine receptors in the same manner as HAL, despite carrying the large polar appendage attached to the HAL scaffold.
