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. 2020 Dec 4;35(1):65–77. doi: 10.1177/0269881120965908

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© The Author(s) 2020

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 3. — Haloperidol (HAL) analog (HAL-F) lacks the property to accumulate in acidic compartments: (a) experimental procedure in hippocampal neurons; (b) representative images of living hippocampal neurons stained with LysoTracker Green (LTG) before (left panel) and after (right panel) HAL; (c) fluorescence intensity (FI). Left: relative FI in relation to before perfusion switch (set as 100%; mean±SEM); Right: light curves represent mean curves over all regions. Bold curves represent mean curves over all measurements per treatment (n=15 per group; ***p< 0.001, two-tailed, unpaired t-test versus dimethyl sulfoxide (DMSO) control).