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. 2020 Dec 4;35(1):65–77. doi: 10.1177/0269881120965908

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© The Author(s) 2020

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 4. — Haloperidol (HAL), but not its non-accumulating analog HAL-F has antipsychotic effects in rodent models of psychosis: (a) treatment plan for induction of amphetamine (AMPH) hypersensitization–induced psychotic-like state and its treatment with osmotic mini pump intracerebroventricular application. Schizophrenia-like behavior was tested by AMPH-induced (intraperitoneally) hyperlocomotion (AIH) and pre-pulse inhibition (PPI); (b) time course of horizontal locomotion; (c) area under the curve (AUC) for locomotor activity during 30 min after the treatment; (d) time course of rearing; (e) AUC for rearing activity during 30 min after the treatment (mean±SEM; n=7–15 per group; *p<0.05, ^#p<0.01, ^$p<0.001 versus AMPH-VEH; ^§p<0.05 versus saline-VEH; VEH – vehicle).