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. 2020 Dec 4;35(1):65–77. doi: 10.1177/0269881120965908

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© The Author(s) 2020

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 5. — Haloperidol (HAL), but not its non-accumulating analog HAL-F, has antipsychotic effects in rodent models of psychosis: (a) amphetamine (AMPH)-hypersensitized animals show reduced pre-pulse inhibition (PPI) of an acoustic startle reflex. HAL enhances PPI in these animals, suggesting antipsychotic efficacy. Less PPI enhancement was observed after subchronic treatment with HAL-F as shown by percentage inhibition for each pre-pulse–pulse pair; (b) overall percentage PPI (background noise = 68 dB; p100–120: pulse intensities 100–120 dB; mean±SEM; n=7–15 per group; *p<0.05, ^#p<0.01 versus AMPH/VEH; VEH – vehicle); (c) HAL-F reached the brain parenchyma in a dose dependent way (**p<0.01); (d) Fluorescent labelled HAL-F (red) accumulating in the dorsal striatum after chronic treatment.