Table 1.

Receptor binding profile of haloperidol (HAL) and the non-accumulating analog HAL-F for human dopamine receptor subtypes.

Ki value (nM), mean ± SEMa
[3H]SCH23390			[3H]spiperone
Compound	D1	D2L	D2S	D3	D4.4
HAL	5.9 ± 1.2	0.64 ± 0.42	0.83 ± 0.27	3.1 ± 0.89	6.1 ± 1.4
HAL-F	3600 ± 1000	30 ± 5.4	13 ± 4.1	68 ± 13	2800 ± 430

^aK_i values derived from 4 to 9 individual experiments, each done in triplicate.