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. 2020 Dec 15;11:604404. doi: 10.3389/fphar.2020.604404

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Copyright © 2020 Yingnan, Gao, Wang, Li, Zhang, Zhu and Liu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Data for mice treated with NMN twice per day (A) The body weights were measured before and after higher NMN administration. (B) The ratio between liver weight and body weight was measured after higher NMN administration. (C) Liver NAD⁺ levels were increased after higher NMN administration. (D–F) Liver function were analyzed after higher NMN administration. (E) Alamine aminotransferase was evaluated in higher NMN-administered mice. (G) Photomicrograph of liver sections from higher NMN-administered mice exhibited normal hepatocytes (H&E stain). (H–J) Kidney function were analyzed after higher NMN administration. (I) Blood urea nitrogen was decreased in 1340 mg/kg/d NMN-administered mice.