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. 2020 Dec 15;11:604404. doi: 10.3389/fphar.2020.604404

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Copyright © 2020 Yingnan, Gao, Wang, Li, Zhang, Zhu and Liu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Transcriptomic Analysis in 1340 mg/kg/d NMN-Administrated Mice Liver (A) Volcano plot shows that genes are differentially expressed in 1340 mg/kg/d NMN-administrated mice compared to control in liver (left panel). Differential expression analysis was performed by DESeq2 from four biological replicates. 45 genes were found to be upregulated (p < 0.05, FC > 1), 29 genes were down regulated (p < 0.05, FC < 1). Gene ontology (GO) analysis were performed by David (right panel). The result shows lipid metabolic process being the biological processes significantly enriched for genes up and down regulated in 1340 mg/kg/d NMN administration group. The bar graphs represent–log10 (p value) and gene counts in each pathway. (B–E) Blood lipids were measured after 1340 mg/kg/d NMN administration.