Table 4.
Hazard ratios (95% CIs) for new-onset diabetes in categories stratified by intratrial mean serum 25(OH)D level in D2d study participants assigned to placebo
| <50 nmol/L (n = 225) | 50–74 nmol/L (n = 378) | 75–99 nmol/L (n = 265) | 100–124 nmol/L (n = 94) | ≥125 nmol/L (n = 22) | |
|---|---|---|---|---|---|
| Median level | 40.0 | 63.8 | 85.0 | 108.4 | 134.1 |
| Model 1 | 1.20 (0.87–1.66) | Reference | 1.09 (0.82–1.46) | 0.69 (0.42–1.14) | 0.64 (0.24–1.75) |
| Model 2 | 1.28 (0.91–1.81) | Reference | 1.05 (0.78–1.41) | 0.68 (0.41–1.14) | 0.60 (0.22–1.67) |
| Model 3 | 1.24 (0.89–1.76) | Reference | 1.05 (0.78–1.41) | 0.69 (0.41–1.16) | 0.62 (0.22–1.73) |
| Model 4 | 1.23 (0.87–1.75) | Reference | 1.04 (0.77–1.39) | 0.67 (0.40–1.13) | 0.48 (0.15–1.56) |
| Model 5 | 1.23 (0.86–1.75) | Reference | 1.03 (0.76–1.38) | 0.67 (0.40–1.12) | 0.47 (0.15–1.52) |
Model 1: no adjustment. Model 2: adjusted for site, BMI (at baseline), race (White, Black, other). Model 3: additionally adjusted for sex and age (at baseline). Model 4: additionally adjusted for physical activity (at baseline). Model 5: additionally adjusted for statin use (at baseline). To convert the values for 25(OH)D to ng/L, divide by 2.496.