Fig. 2.

AMSCs and EVs improve arthritis of joints in mice. The hind paws of IL-1ra^−/− mice, which were administrated AMSCc or EVs, are shown in pictures. The sections of hind paws at a week after the last administration were stained with hematoxylin and eosin. The right panel shows histological appearance of synovial membrane and cartridge surface in mice (a). The thickness of joints of paws in mice was measured a week after the last administration (b). Data were means ± SEM (n = 10 to 15). P-value was determined by unpaired two-tailed student's t-test.