Fig. 1.

The application of BM-MSCs and biomaterials will be an important tissue engineering strategy in the future. (A) BM-MSCs are isolated from bone marrow. (B) BM-MSCs have ability to differentiate into many kinds of cells, like ECs, neural cells and muscle cells. (C) Scientists have tried to transplant BM-MSCs and biomaterials together into injured muscles. (D) Biomaterials are able to protect BM-MSCs from the immune system. (E) After the degradation of biomaterials, BM-MSCs continue to differentiate at injured sites. (F) The processes of vascularization, innervation and muscularization are activated to form regenerative tissues.