TABLE 2.
A summary of current clinical trials for aerosolized liposomes.
| NP | APIs | Target disease | Phase | Status | Sponsor | Identifier |
|---|---|---|---|---|---|---|
| 9-Nitro-20 (S)-Camptothecin (L9NC) liposomes | N/A | Non-small-cell lung cancer | II | Completed in 2007 | University of New Mexico | NCT00250120 |
| 9-Nitro-20 (S)-Camptothecin (L9NC) liposomes | N/A | Metastatic endometrial cancer | II | Completed in 2007 | University of New Mexico | NCT00249990 |
| AmBisome | N/A | ABPA | II | Completed in 2019 | Poitiers university hospital | NCT02273661 |
| AmBisome | Intraconazole | ABPA | III | Recruiting | Poitiers university hospital | NCT03656081 |
| AmBisome | N/A | Lung transplant infections | II | Completed in 2014 | University health network, toronto | NCT01254708 |
| AmBisome | N/A | Lung transplant infections | III | Completed in 2007 | University of Pittsburgh | NCT00177710 |
| Arikayce | N/A | Cystic fibrosis | I/II | Completed in 2008 | Insmed incorporated | NCT00777296 |
| Arikayce | N/A | Cystic fibrosis | I/II | Completed in 2009 | Insmed incorporated | NCT00558844 |
| Arikayce | N/A | Cystic fibrosis | II | Completed in 2010 | Insmed incorporated | NCT03905642 |
| Arikayce | Mycobacterial multi-drug regimen | Mycobacterium abscessus lung disease | II | Completed in 2019 | Kevin winthrop | NCT03038178 |
| Arikayce | Mycobacterial multi-drug regimen | NTM + MAC | III | Completed in 2018 | Insmed incorporated | NCT02628600 |
| Bupivacaine liposomes | N/A | Coronary heart disease | III | Completed in 2020 | Kathirvel subramaniam | NCT03270514 |
| Cisplatin liposome | N/A | Osteosarcoma metastatic | I/II | Completed in 2008 | Insmed incorporated | NCT00102531 |
| Cyclosporin liposome | N/A | Bronchiolitis obliterans syndrome | II/III | Completed in 2014 | Pari Pharma GmbH | NCT01334892 |
| Cyclosporin liposome | Tacrolimus + mycophenolate mofetil prednisone + rampamycin | Lung transplant rejection | I/II | Completed in 2015 | University of Maryland, college Park | NCT01650545 |
| Pulmaquin | N/A | Non-cystic fibrosis bronchiectasis | III | Completed in 2016 | Aradigm corporation | NCT02104245 |
| Pulmaquin | N/A | Non-cystic fibrosis bronchiectasis | III | Completed in 2016 | Aradigm corporation | NCT01515007 |
AmBisome, amphotericin B liposome; ABPA, allergic bronchopulmonary aspergillosis; NTM, nontuberculous mycobacterial lung infection; Pulmaquin, ciprofloxacin liposome.