Figure 6.

Repeated fluoxetine administration reversed the promoting effects of chronic social defeat stress (CSDS) on the LIMK-Cofilin signaling in the medial prefrontal cortex (mPFC) of mice. (A) Fluoxetine produced antidepressant-like actions in the CSDS model of depression, as revealed by the forced swim test (FST), tail suspension test (TST), sucrose preference test, and social interaction test (n = 10). (B) Representative western blotting images indicate that the (CSDS + fluoxetine)-treated mice had significantly less expression of pLIMK1, pLIMK2, and pCofilin in the mPFC than the CSDS-treated mice (n = 5). The levels of total LIMK1, LIMK2, and Cofilin in the mPFC remained unchanged among all groups (n = 5). All results are expressed as the means ± SEM; *P < .05, **P < .01; n.s., no significance. The comparisons were made by 2-way ANOVA followed by Bonferroni’s test.