Table 1.

Tight junction and adherens junction protein changes after SAH.

Models	Changes	Interventions	Refs.
Rat/EP	Occludin redistribution (IHC)	Glibenclamide	Simard et al. [62]
Rat/BI	Occludin/ZO-1 ↓ (WB) 48h	HIF-1α, MMPs, aquaporin-4	Wang et al. [63]
Rat/EP	Occludin/ZO-1 ↓ (WB/IHC) 24h	c-Jun N-terminal kinase inhibition	Chen et al. [64]
Mice/EP	Claudin-5/ZO-1/JAM-A/VE-cadherin ↓ (WB) 24h	Isoflurane	Altay et al. [65]
Rat/EP	Occludin/ZO-1/claudin-5 ↓ (WB) 24h	Melatonin	Chen et al. [66]
Rat/EP	Occludin/ZO-1 ↓, claudin-1/5 ↔ (WB, IHC) 0.5 – 168h	None	Li et al. [7]
Rat/EP	Occludin/ZO-1/claudin-5/VE-cadherin ↓ (WB, IHC) 24h	Norrin/frizzled-4	Chen et al. [67]
Mice/EP	ZO-1/VE-cadherin ↓ (WB, IHC) 24 h	Thrombomodulin	Xu et al. [68]
Rat/EP	ZO-1 ↓ (WB) 24h	Progranulin	Zhou et al. [69]
Rat/BI	ZO-1 ↓ (WB) 24h	Fisetin (flavonoid)	Zhou et al. [70]
Rat/BI	Claudin-5/occludin ↓ (WB) 24h	PARP inhibition	Chen et al. [71]
Mice/EP	ZO-1 ↓ (WB) 24 h	Tenascin-C	Fujimoto et al. [72]
Rat/EP	Claudin-5/occludin ↓ (WB) 24h	Ethyl pyruvate	Fang et al. [73]
Rat/EP	Claudin-5/occludin ↓ (WB) 24h	Valproic acid	Ying et al. [74]
Rat/BI	Occludin/ZO-1 ↓	Matrine (alkaloid)	Liu et al. [75]
Mice/EP	Occludin/ZO-1/claudin-5 ↓ (WB) 48h	Apolipoprotein E	Pang et al. [76]
Mice/EP	Occludin/ZO-1 ↓ (WB) 24h	Curcumin	Yuan et al. [77]
Rat/EP	Claudin-5/ZO-1 ↓ (WB) 24h	Eph receptor-A4/Fasudil (ROCK inhibition)	Fan et al. [78]
Rat/EP	ZO-1 ↓ (IHC) 24 h	Tropomyosin-related kinase receptor B activation	Qi et al. [59]
Rat/EP	Occludin/Claudin-5 ↓(WB) 24h	Nrg1 isoform β1	Qian et al. [79]

↓: decrease; ↔: no change; EP: endovascular perforation; BI: blood injection; WB: western blot; IHC: immunohistochemistry; ROCK: RhoA kinase; HIF-1a: hypoxia-inducible factor-1a; MMPs: matrix metalloproteinases; PARP: Poly (ADP-ribose) polymerase.