Fig. 6.

Ablation of colon cancer by ¹²⁴I-Au@AuCB-labeled macrophage-mediated PTT. a Scheme for ¹²⁴I-Au@AuCB-labeled macrophage-mediated PTT in vivo. In vivo PET/CT imaging of CT26/FM tumor-bearing mice, intratumorally injected with ¹²⁴I-Au@AuCB-labeled macrophages. Experimental groups: (1) control, (2) laser alone, (3) ¹²⁴I-Au@AuCB-labeled macrophages, (4) ¹²⁴I-Au@AuCB-labeled macrophages + laser-treated, and (5) macrophages + laser-treated. b In vivo FLI showing the therapeutic response to ¹²⁴I-Au@AuCB-labeled macrophage-mediated PTT. c PET/CT imaging of CT26/FM tumor-bearing mice administered either unlabeled or labeled macrophages and subsequently irradiated with an NIR laser (6 W cm⁻², 5 min). d Temperature and e temperature changes (Δ temperature) in CT26/FM tumors, before and after irradiation with an NIR laser (6 W cm⁻², 5 min). f Quantification of FLI signals in CT26/FM tumors, before and after PTT. g Photograph of an excised CT26/FM tumor and determination of tumor weight from respective groups. In vivo experiments were performed in duplicate (n = 7 mice per group). ***P < 0.0001