Fig. 7.

Anti-tumor activity of CFN-gel combined with PDT in vivo. a Left: tumor growth curves of mice. Control group (n = 7), free Ce6 + PDT (n = 5), CFN-gel (n = 7) and CFN-gel + PDT (n = 5). PBS, free Ce6 or Ce6–fucoidan was injected intravenously on day 1. Light illumination (670 nm, 50 mW cm⁻², 20 J cm⁻²) of the tumors was conducted on day 2 for PDT. Right: representative photographs of the mice obtained on day 10, b immunohistochemical staining of CD31 (for tumor blood vessels) and TUNEL (for apoptotic cell death) of tumor sections collected from different groups of mice at 24 h after PDT, c left: micrographs of immunohistochemical staining of CD31 and TUNEL-stained tumor sections collected from control and CFN-gel groups of mice at day 7. Right: quantitative analysis of CD31 and TUNEL assays in the tumor sections. **P < 0.01, ***P < 0.001