Selection of histone marks and histone modifying enzymes (HMEs) associated with transcription: | ||||||
Mark | Function | Location | Writer Family | Eraser Family | Writers | Erasers |
H3K4me1 | Facultative euchromatin | Enhancers | KMT2 KMT3 KMT7 |
KDM1 KDM5 |
SETD1A MLL1–4 SMYD2 SETD7/9 |
LSD1/2 JMJD9 JARID1B |
H3K4me3 | Facultative euchromatin | Promoters | KMT2 KMT8 |
KDM5 | SETD1A/B MLL1/2 PRDM9 |
JMJD9 JARID1A-D |
H3K27ac | Active transcription | Promoters & Enhancers | KAT3 (HAT) | HDAC | EP300 CREBBP |
HDAC3 |
H3K36me3 | Active transcription | Genebody | KMT3 | KDM4 | SETD2 | JMJD2A-E |
H3K79me2 | Active transcription | Genebody | KMT4 | Unknown | DOT1L | Unknown |
Selection of histone marks and HMEs associated with gene silencing: | ||||||
Mark | Function | Location | Writer Family | Eraser Family | Writers | Erasers |
H3K9me2 | Facultative heterochromatin | Gene deserts | KMT1 | KDM3 KDM4 |
G9a GLP-1 |
JMJD1A JMJD2D-E |
H3K9me3 | Constitutive heterochromatin | Intergenic domains promoters enhancers | KMT1 | KDM3 KDM4 |
SUV39H1/2 SETDB1 |
JMJD1B JMJD2A-E |
H3K27me3 | Facultative heterochromatin | Intergenic domains (bivalent) promoters enhancers | KMT6 | KDM6 | EZH1/2 | UTX UTY JMJD3 |
HME families:
KMT: Lysine methyl transferase
KDM: Lysine demethylase
KAT: Lysine acetyl transferase
HAT: Histone acetyl transferase
HDAC: Histone deacytelase