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. 2020 Nov 4;63(24):15075–15093. doi: 10.1021/acs.jmedchem.0c00812

Figure 4.

Figure 4

Concentration-dependent responses to VLX1570. (A) Induction of polyubiquitinated proteins in RS4;11 ALL cells. Note strong increases of polyubiquitin and induction of Hsp70 at 250 nM VLX1570. (B) Increases in p21Cip1, LYN, and HMOX1. RS4;11 cells were exposed to VLX1570, and different markers were analyzed in the same extracts using a PCR-based multiplex method (OLINK, Uppsala, Sweden). Note the increases of HMOX1 at 50–100 nM VLX1570 and the decreases of all markers at high concentrations. Figure from ref (157), which licensed under CC BY 3.0.