Scheme 1.

Design and proposed an active mechanism of autophagy inhibition and self-sensitization. (1) Preparation of HA-coated miR-101/PNs complexes (HA-PNplex): miR-101 is condensed on the PNs, followed by HA coating. (2) HA-PNplex is administered via intravenous injection (i.v.), accumulate in the tumor site, and (3) enter cancer cells through CD44-receptor-mediated caveolar endocytosis. (4) HA-PNplex release miR-101 and PTX, with miR-101 suppressing the autophagy (5) and, in turn, sensitizing the cancer cells (6) to the anti-tumor carriers, PNs