. 2020 Jul 5;12:142. doi: 10.1007/s40820-020-00482-6

Table 3.

Advantages and disadvantages of the three approaches in chemoimmunotherapy

Approach	Advantages	Disadvantages
“Free drug + nano” approach	1. Adjustable prescription 2. Adjustable administration interval 3. Easy for preparation 4. Easy for industrial scale-up	1. Undesired distribution of two agents in vivo 2. Uncontrolled onset time 3. Insufficient tumor selectivity 4. Potential systemic toxicity
“Nano + nano” approach	1. Flexibility in formulation 2. Adjustable administration dosing 3. Coordinated distribution of two agents in vivo	1. Mismatched half-lives and in vivo pharmacokinetics 2. Uncontrollable onset time in tumor tissue
Co-encapsulation approach	1. Uniform distribution of the drugs in vivo 2. Accumulation in the tumor tissue at proper ratio 3. Drug release in a controlled manner 4. Controlled temporal and spatial delivery of multiple agents	1. Complex preparation process 2. Difficulty in delivering to different targets

Approach

Advantages

Disadvantages

“Free drug + nano” approach

1. Adjustable prescription

2. Adjustable administration interval

3. Easy for preparation

4. Easy for industrial scale-up

1. Undesired distribution of two agents in vivo

2. Uncontrolled onset time

3. Insufficient tumor selectivity

4. Potential systemic toxicity

“Nano + nano” approach

1. Flexibility in formulation

2. Adjustable administration dosing

3. Coordinated distribution of two agents in vivo

1. Mismatched half-lives and in vivo pharmacokinetics

2. Uncontrollable onset time in tumor tissue

Co-encapsulation approach

1. Uniform distribution of the drugs in vivo

2. Accumulation in the tumor tissue at proper ratio

3. Drug release in a controlled manner

4. Controlled temporal and spatial delivery of multiple agents

1. Complex preparation process

2. Difficulty in delivering to different targets