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. 2020 Jun 16;12:127. doi: 10.1007/s40820-020-00452-y

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — The excellent biological properties of iPS-MnO₂@Ce6. a Confocal laser microscopy images of oxygen-sensing probe ([(Ru (dpp)₃)]Cl₂) in iPS cells showing the intracellular oxygen level incubated with nanoprobes for the indicated time. Scale bars are 50 μm. b Fluorescence images of Calcein AM (green)/PI(red) stained iPS cells incubated with free Ce6, MnO₂, and nanoprobes. Scale bars are 50 μm. c Photoacoustic imaging showing saturated O₂ (sO₂) levels in tumors after injection of MnO₂@Ce6 and iPS-MnO₂@Ce6 at different time points. d The quantified tumor oxygen saturation levels calculated from c. Data were expressed as mean ± SD, (n = 3, *P < 0.05). e Representative immunofluorescence images of tumor sections after hypoxia staining. The nuclei and hypoxia regions were stained by DAPI (blue) and anti-pimonidazole antibody (green), respectively. Scale bars are 100 μm. (Color figure online)