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. Author manuscript; available in PMC: 2020 Dec 29.
Published in final edited form as: Cell Rep. 2020 Apr 7;31(1):107481. doi: 10.1016/j.celrep.2020.03.045

Figure 1. Two-Cell Model for Inflammasome-Independent IL-1β Release.

Figure 1.

Inflammasome-dependent and -independent IL-1β maturation and secretion require two signals. Signal 1 is shared by both mechanisms, which involves microbe recognition by a TLR and the upregulation of pro-IL-1β production. Signal 2 distinguishes inflammasome-dependent and -independent mechanisms. See text for details.