Fig. 1.

a. Sisu study design. b. Study-specific Trier Social Stress Test (TSST) procedures. c. CONSORT flow diagram. Abbreviations: AEs, Adverse Events; BAI, Beck Anxiety Inventory; BMI, Body Mass Index; BP, Blood Pressure; CAR, Cortisol Awakening Response; CONSORT, Consolidated Standards of Reporting Trials; DASS, Depression Anxiety Stress Scale; ITT, Intention to Treat; PP, Per Protocol; PSS, Perceived Stress Scale; STAI, State Trait Anxiety Inventory; TICS, Trier Inventory for Chronic Stress; VAS, Visual Analog Scale.