Table 2.
Summary measures in response to the Trier Social Stress Test (TSST) for participants in the Per Protocol population.
| Sitting pre-TSST−20 min |
Standing pre-TSST−10 min |
Pre-TSST−3 min |
Pre-TSST−2 min |
Interview TSST |
Arithmetic TSST |
Post-TSST+1 min |
Standing post-TSST +10 min |
Sitting post-TSST+20 min |
Post-TSST+30 min |
Post-TSST+45 min |
P | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Mean (SD) | Mean (SD) | Mean (SD) | Mean (SD) | Mean (SD) | Mean (SD) | Mean (SD) | Mean (SD) | Mean (SD) | Mean (SD) | Mean (SD) | ||
|
Heart Rate (bpm) | ||||||||||||
| Placebo (n = 57) | 74.34 (9.04) | 86.69 (10.74) | 97.62 (16.23) | – | 105.66 (18.86) | 100.81 (17.20) | – | 90.81 (12.11) | 74.97 (9.86) | – | – | 0.757T |
| Lpc-37 (n = 55) |
74.84 (10.20) |
88.15 (11.13) |
97.34 (17.15) |
– |
107.56 (21.56) |
102.77 (19.57) |
– |
93.32 (14.08) |
75.88 (11.11) |
– |
– |
|
|
Salivary Cortisol (nmol/L) | ||||||||||||
| Placebo (n = 57) | – | – | – | 4.82 (2.60) | – | – | 6.85 (3.50) | 8.97 (5.84) | 9.21 (6.59) | 7.71 (5.06) | 6.16 (3.79) | 0.566T |
| Lpc-37 (n = 55) |
– |
– |
– |
4.79 (2.62) |
– |
– |
6.96 (3.73) |
9.48 (5.75) |
9.89 (6.51) |
8.04 (5.36) |
6.21 (3.17) |
|
|
Salivary Alpha Amylase (U/ml) | ||||||||||||
| Placebo (n = 57) | – | – | – | 161.67 (110.89) | – | – | 270.55 (174.85) | 158.85 (91.21) | 141.49 (93.00) | 138.48 (90.31) | 148.15 (105.60) | 0.815T |
| Lpc-37 (n = 55) |
– |
– |
– |
154.04 (98.17) |
– |
– |
246.29 (153.62) |
146.53 (86.80) |
130.11 (82.45) |
125.19 (79.67) |
141.13 (92.94) |
|
|
Systolic BP (mmHg) | ||||||||||||
| Placebo (n = 58) | – | – | 114.33 (14.07) | – | – | – | 129.19 (14.33) | – | – | – | – | 0.274 |
| Lpc-37 (n = 55) |
– |
– |
115.11 (12.53) |
– |
– |
– |
127.47 (13.67) |
– |
– |
– |
– |
|
|
Diastolic BP (mmHg) | ||||||||||||
| Placebo (n = 58) | – | – | 78.41 (8.32) | – | – | – | 88.36 (9.72) | – | – | – | – | 0.345 |
| Lpc-37 (n = 55) |
– |
– |
79.13 (7.83) |
– |
– |
– |
90.38 (7.17) |
– |
– |
– |
– |
|
|
STAI-State (score) | ||||||||||||
| Placebo (n = 58) | – | 36.83 (9.48) | – | – | – | – | 43.60 (10.00) | – | – | – | – | 0.755 |
| Lpc-37 (n = 55) |
– |
36.09 (8.45) |
– |
– |
– |
– |
42.38 (10.91) |
– |
– |
– |
||
|
VAS Stress (score) | ||||||||||||
| Placebo (n = 58) | – | 18.52 (21.73) | – | – | 51.51 (28.10) | – | 32.85 (23.66) | – | – | – | – | 0.327T |
| Lpc-37 (n = 55) |
– |
19.89 (20.61) |
– |
– |
47.71 (27.08) |
– |
31.72 (24.25) |
– |
– |
– |
– |
|
|
VAS Insecurity (score) | ||||||||||||
| Placebo (n = 58) | – | 17.19 (21.37) | – | – | 52.19 (27.16) | – | 23.69 (23.58) | – | – | – | – | 0.364T |
| Lpc-37 (n = 55) |
– |
14.47 (16.96) |
– |
– |
45.08 (28.92) |
– |
23.92 (23.87) |
– |
– |
– |
– |
|
|
VAS Anxiety (score) | ||||||||||||
| Placebo (n = 58) | – | 8.50 (14.94) | – | – | 22.47 (23.51) | – | 11.74 (18.46) | – | – | – | – | 0.251T |
| Lpc-37 (n = 55) |
– |
6.80 (10.95) |
– |
– |
20.85 (23.61) |
– |
10.68 (15.19) |
– |
– |
– |
– |
|
|
VAS Exhaustion (score) | ||||||||||||
| Placebo (n = 58) | - | 19.79 (21.88) | – | – | 21.30 (22.47) | – | 25.68 (26.07) | - | - | - | - | 0.101T |
| Lpc-37 (n = 55) | – | 21.18 (21.49) | – | – | 19.20 (21.11) | – | 22.12 (22.46) | – | – | – | – | |
Abbreviations: BP, Blood Pressure; n, number of participants; SD, Standard Deviation; STAI; State-Trait Anxiety Inventory; TSST, Trier Social Stress Test; VAS, Visual Analog Scale.
T Outcome was subjected to transformation to meet model assumptions.