Fig. 2.

Regional gray matter volume is associated with the (A) visuo-spatial, (B) executive, (C) working memory, (D) memory, and (E) language domains respectively. Figure (F) and (G) shows the association of gray matter volume with the clock drawing and clock copy subtest of visuospatial function respectively. Voxel-wise multiple comparisons are thresholded at p < .01, FDR corrected for only figures a-e, cluster size ≥ 50 voxels, 0.38 ≤ d ≤ 0.70. Figures F and G are displayed at p < .001, 0.38 ≤ d ≤ 0.50 uncorrected for multiple comparisons. Red voxels show clusters of significant association between gray matter volume and cognitive domain scores. Statistical maps are superimposed on a rendering of the Montreal Neurological Institute template brain. MNI coordinates and corresponding t values are provided in Supplementary Table 2. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)