Table 1.
Selective Indexes for different cell types after treatment with TST and SAHA for 48h.
| Compounds |
T. gondii EGS |
T. gondii RH |
Cell Types |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| LLCMK2 |
Macrophages |
NDHF |
Primary microglial |
||||||||
| IC50 [μM] | IC50 [μM] | aCC50 [μM] | bSIc | aCC50 [μM] | SIc | aCC50 [μM] | SIc | aCC50 [μM] | SIc | ||
| TST | 0.29 | 0.52 | >20 | >38 | 13.50 | 26 | >20 | >39 >69d |
>20 | >39 | |
| SAHA | 0.04 | 0.07 | 5.94 | 89 | 4.61 | 68 | >20 | >30 >500d |
>20 | >30 | |
a
CC50: Concentration necessary to kill 50% of the cells.
b
SI: Selective index = CC₅₀/IC₅₀.
c
Calculated with IC50 of the RH strain.
d
Calculated with IC50 of the EGS strain (atypical).