Table 1.

Summary of the phenotype and function of cDCs found in human and mouse TDLNs and tumors: cDC1s, cDC2s and inflammatory cDC2s

Conventional DC subset	Phenotype	Phenotype	Proposed function	Proposed function
	Human	Mouse	TDLN	Tumor
cDC1	CD11c+, HLA-DR+, CD141+, CLEC9a+	CD11c+, MHC-II+, XCR1+, CD8a+, CD103+/−	Priming/primary activation of CD8 T cells Cross-presentation	Migration from tumor to deliver tumor antigens to TDLN Associated with tumor control and better patient survival
cDC2	CD11c+, HLA-DR+, CD1c+, CLEC10a+ pro-inflammatory subset: CD14+ CD163+	CD11c+, MHC-II+, CD11b+, CD16−	Priming/activation of CD4 T cells	Most abundant population within tumors Lineage differentiation of CD4 T cells via diverse cytokine secretion Support stem-like CD8 T cells within lymphoid-like niches in the tumor Pro-inflammatory cytokine secretion from CD14+ CD163+ cDC2s

The function and primary location of each of these DCs are expanded upon in the main text.