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. Author manuscript; available in PMC: 2021 Apr 26.
Published in final edited form as: Biochemistry. 2020 May 11;59(20):1871–1880. doi: 10.1021/acs.biochem.0c00159

Figure 1.

Figure 1.

BPTF engages chromatin through multiple domains that recognize specific potential histone PTMs, including those on H2A.Z. (A) Domain diagram of BPTF showing its DNA binding and differential transcription factor domain (DDT), two PHD domains, and the bromodomain (BRD). Shown below are the histone modifications that have been characterized to interact with the C-terminal PHD domain and BRD. (B) Sequence alignment of the N-terminal tails of H2A.Z isoforms with their divergent amino acids highlighted in yellow. Shown above the sequence are their known post-translational modifications.