Table 4.

Validated and potential drug targets in Filoviridae and NP Inhibitors. Numbering corresponds to numbering in Figure 2. Roman numbering corresponds to numbering in Figure1. Numbers in parenthesis corresponds to structures in Figures 5–10

	Number	Target Protein	Function	Natural Product Inhibitors	NP-Inspired Inhibitors
Viral Proteins	I	VP35	Polymerase cofactor responsible for transcription and replication with L protein	myricetin (26), epigallocatechingallate (31)	Inhibitors Needed
	II	VP40	Matrix protein involved in budding	Inhibitors Needed	Inhibitors Needed
	III	GP	Host cell recognition	ellagic acid (6), gallic acid (7), cyanovirin-N (11)	triterpenoid derivatives (8, 9), a borneol derivative (10)
	IV	VP30	Transcriptional activator	Inhibitors Needed	Inhibitors Needed
	V	VP24	Structural protein. Important role in nucleocapsid formation	Inhibitors Needed	Inhibitors Needed
	VI	L protein	RNA-dependent RNA polymerase	Inhibitors Needed	favipiravir (22), remdesivir (1), BCX4430 (30)
Host Proteins	VII	Cathepsin B / Cathepsin L	Endosomal protease. Cleaves spike protein facilitating membrane fusion & entry	gallinamide A (35), tokaramide A (39), miraziridine A (40)	dichlorobenzyl aloperine dihydrochloride (41), E-64d (42), CA074 (43)