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. 2020 Dec 29;104:433–440. doi: 10.1016/j.ijid.2020.12.073

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© 2021 The Authors

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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(a) Changes over time in immune response-related markers: comparison between Cohort 1 and Cohort 2 (T0: basal; T1 after first administration of canakinumab; T2 after 7–10 days from the second administration of canakinumab). The N/L ratio is also reported. (b) Changes over time in immune-inflammatory-related biomarkers: comparison between Cohort 1 and Cohort 2.