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. Author manuscript; available in PMC: 2021 Mar 26.
Published in final edited form as: J Med Chem. 2020 Mar 6;63(6):3227–3237. doi: 10.1021/acs.jmedchem.9b01980

Figure 4.

Figure 4.

Binding modes of BRD7/9 inhibitors in BRD4. (A) Cocrystal structure of BI-7273 with BRD4-1 (PDB 6V1K) and superposition with the BRD7/BI-7273 complex (PDB 6V1E). (B) Same as (A) for BI-9564 (PDB 6V1L and 6V1F). (C) Same as (A) for TP-472 (PDB 6V1U and 6V16). (D) Same as (A) for bromosporine (PDB 6V0U and 6V1H). All structures were determined experimentally. Residues of BRD4 are shown in green and of BRD7 in beige. Inhibitor liganded with BRD4 is shown in yellow and liganded with BRD7 in orange. 2Fo – Fc and Fo – Fc electron density maps are shown in the Supporting Information Figure S5.