Table 3.
Estimated HRs and 95% CIs for the association between each patient characteristic and risk of all-cause mortality by survival time interval and by histotype (HGSC and non-HGSC), 2004–2016, SEER 18 Registries (N = 35,868).
| Survival time | p-Trend | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| t < 3 years | 3 ≤ t < 6 years | 6 ≤ t < 9 years | 9 ≤ t < 13 years | |||||||
| Patient characteristics | Cases | Deaths | HR (95% CI) | Deaths | HR (95% CI) | Deaths | HR (95%CI) | Deaths | HR (95%CI) | |
| HGSC | ||||||||||
| Age at diagnosis | ||||||||||
| <50 years | 2950 | 657 | 0.79 (0.72,0.86) | 513 | 0.90 (0.81,1.00) | 136 | 0.97 (0.78,1.19) | 31 | 0.98 (0.63,1.52) | 0.02 |
| 50 to 59 years | 6195 | 1803 | 1.00 (Referent) | 1038 | 1.00 (Referent) | 243 | 1.00 (Referent) | 54 | 1.00 (Referent) | |
| 60 to 69 years | 7193 | 2595 | 1.24 (1.17,1.32) | 1073 | 1.02 (0.94,1.11) | 244 | 1.07 (0.89,1.28) | 47 | 1.06 (0.72,1.58) | 0.01 |
| ≥70 years | 7666 | 3614 | 1.59 (1.50,1.69) | 989 | 1.09 (1.00,1.20) | 227 | 1.20 (1.00,1.45) | 74 | 1.77 (1.23,2.54) | 0.99 |
| Region of residencea | ||||||||||
| Northeast | 5918 | 2166 | 1.00 (Referent) | 934 | 1.00 (Referent) | 207 | 1.00 (Referent) | 44 | 1.00 (Referent) | |
| Northwest | 1692 | 597 | 0.93 (0.85,1.02) | 270 | 0.94 (0.82,1.07) | 71 | 1.05 (0.80,1.37) | 17 | 1.13 (0.64,2.00) | 0.40 |
| Southeast | 4905 | 1891 | 1.00 (0.94,1.06) | 728 | 0.96 (0.87,1.06) | 163 | 0.92 (0.75,1.13) | 46 | 1.14 (0.75,1.74) | 0.66 |
| Southwest | 11,489 | 4015 | 0.98 (0.93,1.03) | 1681 | 0.91 (0.83, 0.98) | 409 | 0.89 (0.75,1.06) | 99 | 0.93 (0.65,1.35) | 0.13 |
| Marital status | ||||||||||
| Married | 13,501 | 4307 | 1.00 (Referent) | 2151 | 1.00 (Referent) | 517 | 1.00 (Referent) | 130 | 1.00 (Referent) | |
| Never married | 4052 | 1417 | 1.20 (1.13,1.27) | 507 | 0.93 (0.85,1.03) | 137 | 1.01 (0.84,1.23) | 31 | 0.93 (0.63,1.39) | 0.04 |
| Widowed | 3410 | 1749 | 1.35 (1.27,1.43) | 472 | 1.24 (1.12,1.38) | 94 | 1.15 (0.92,1.45) | 27 | 1.12 (0.73,1.72) | 0.05 |
| Separated/divorced | 3041 | 1196 | 1.25 (1.17,1.33) | 483 | 1.25 (1.17,1.33) | 102 | 1.25 (1.13,1.38) | 18 | 1.09 (0.66,1.80) | 0.83 |
| Race/ethnicityb | ||||||||||
| Non-Hispanic White | 17,483 | 6438 | 1.00 (Referent) | 2732 | 1.00 (Referent) | 662 | 1.00 (Referent) | 164 | 1.00 (Referent) | |
| Non-Hispanic Black | 1828 | 806 | 1.21 (1.12,1.30) | 249 | 1.13 (0.99,1.29) | 45 | 0.93 (0.68,1.26) | 11 | 0.91 (0.49,1.70) | 0.07 |
| Non-Hispanic Asian/Pacific Islander | 1696 | 498 | 0.93 (0.85,1.02) | 228 | 1.00 (0.87,1.14) | 44 | 0.80 (0.59,1.10) | 12 | 0.95 (0.52,1.74) | 0.96 |
| Hispanic - all races | 2839 | 870 | 0.88 (0.81,0.94) | 376 | 0.92 (0.82,1.03) | 94 | 0.98 (0.79,1.23) | 19 | 0.85 (0.52,1.39) | 0.37 |
| Stage at diagnosis | ||||||||||
| Localized | 1127 | 78 | 1.00 (Referent) | 58 | 1.00 (Referent) | 33 | 1.00 (Referent) | 10 | 1.00 (Referent) | |
| Regional | 3639 | 548 | 2.21 (1.75,2.81) | 361 | 2.40 (1.82,3.17) | 128 | 1.80 (1.23,2.64) | 48 | 2.52 (1.27,4.98) | 0.76 |
| Distant | 19,238 | 8043 | 6.12 (4.90, 7.66) | 3194 | 6.98 (5.38, 9.05) | 689 | 4.62 (3.25,6.55) | 148 | 4.61 (2.42,8.78) | 0.21 |
| Surgery of primary site | ||||||||||
| No | 2541 | 1905 | 3.86 (3.66,4.07) | 144 | 1.46 (1.23,1.72) | 16 | 0.96 (0.58,1.58) | 7 | 2.05 (0.94,4.49) | 0.07 |
| Yes | 21,463 | 6764 | 1.00 (Referent) | 3469 | 1.00 (Referent) | 834 | 1.00 (Referent) | 199 | 1.00 (Referent) | |
| Non-HGSCc | ||||||||||
| Age at diagnosis | ||||||||||
| <50 years | 2627 | 352 | 0.84 (0.74,0.96) | 134 | 0.84 (0.67,1.04) | 50 | 0.90 (0.63,1.28) | 16 | 0.69 (0.38,1.28) | 0.86 |
| 50 to 59 years | 3761 | 623 | 1.00 (Referent) | 215 | 1.00 (Referent) | 74 | 1.00 (Referent) | 30 | 1.00 (Referent) | |
| 60 to 69 years | 2485 | 485 | 1.02 (0.90,1.15) | 173 | 1.20 (0.98,1.48) | 57 | 1.25 (0.88,1.78) | 26 | 1.71 (1.00,2.92) | 0.02 |
| ≥70 years | 2991 | 697 | 1.27 (1.14,1.43) | 224 | 1.39 (1.15,1.69) | 101 | 1.90 (1.40,2.58) | 40 | 2.12 (1.31,3.42) | 0.004 |
| Region of residencea | ||||||||||
| Northeast | 2849 | 490 | 1.00 (Referent) | 189 | 1.00 (Referent) | 88 | 1.00 (Referent) | 28 | 1.00 (Referent) | |
| Northwest | 681 | 109 | 1.01 (0.82,1.24) | 34 | 0.91 (0.63,1.32) | 10 | 0.52 (0.27,1.00) | 3 | 0.47 (0.14,1.53) | 0.04 |
| Southeast | 2176 | 445 | 1.14 (1.00,1.30) | 156 | 1.13 (0.91,1.40) | 47 | 0.71 (0.49,1.01) | 22 | 0.97 (0.55,1.71) | 0.08 |
| Southwest | 6158 | 1113 | 1.14 (1.02,1.27) | 367 | 1.01 (0.84,1.21) | 137 | 0.76 (0.57,1.01) | 59 | 1.23 (0.78,1.95) | 0.08 |
| Marital status | ||||||||||
| Married | 6449 | 1040 | 1.00 (Referent) | 385 | 1.00 (Referent) | 155 | 1.00 (Referent) | 62 | 1.00 (Referent) | |
| Never married | 3077 | 548 | 1.07 (0.96,1.19) | 177 | 1.07 (0.90,1.29) | 56 | 0.82 (0.60,1.11) | 21 | 0.84 (0.51,1.40) | 0.14 |
| Widowed | 1038 | 300 | 1.32 (1.16,1.52) | 102 | 1.50 (1.20,1.88) | 45 | 1.78 (1.26,2.50) | 14 | 1.41 (0.78,2.54) | 0.16 |
| Separated/divorced | 1300 | 269 | 1.13 (0.98,1.29) | 82 | 1.03 (0.81,1.31) | 26 | 0.86 (0.57,1.30) | 15 | 1.46 (0.83,2.58) | 0.76 |
| Race/ethnicityb | ||||||||||
| Non-Hispanic White | 7947 | 1394 | 1.00 (Referent) | 540 | 1.00 (Referent) | 206 | 1.00 (Referent) | 96 | 1.00 (Referent) | |
| Non-Hispanic Black | 714 | 226 | 1.45 (1.25,1.67) | 54 | 1.38 (1.04,1.83) | 16 | 1.32 (0.79,2.19) | 5 | 0.94 (0.38,2.31) | 0.79 |
| Non-Hispanic Asian/Pacific Islander | 1494 | 230 | 0.93 (0.80,1.07) | 67 | 0.73 (0.56, 0.95) | 34 | 0.97 (0.66,1.42) | 5 | 0.28 (0.11,0.70) | 0.11 |
| Hispanic - all races | 1638 | 293 | 1.04 (0.92,1.19) | 83 | 0.96 (0.75,1.22) | 24 | 0.83 (0.54,1.29) | 6 | 0.45 (0.20,1.05) | 0.06 |
| Stage at diagnosis | ||||||||||
| Localized | 4637 | 223 | 1.00 (Referent) | 173 | 1.00 (Referent) | 89 | 1.00 (Referent) | 49 | 1.00 (Referent) | |
| Regional | 4163 | 459 | 2.45 (2.09, 2.88) | 238 | 1.85 (1.52,2.25) | 90 | 1.54 (1.15,2.06) | 31 | 0.94 (0.60,1.49) | <0.0001 |
| Distant | 3064 | 1475 | 12.47 (10.79,14.41) | 335 | 7.02 (5.82, 8.45) | 103 | 5.35 (4.02,7.12) | 32 | 3.25 (2.07, 5.09) | <0.0001 |
| Surgery of primary site | ||||||||||
| No | 404 | 319 | 3.78 (3.31,4.32) | 16 | 2.13 (1.29,3.53) | 3 | 1.25 (0.40,3.95) | 0 | N/A | 0.005 |
| Yes | 11,460 | 1838 | 1.00 (Referent) | 730 | 1.00 (Referent) | 279 | 1.00 (Referent) | 112 | 1.00 (Referent) | |
SEER: Surveillance, Epidemiology, and End Results; HR: hazard ratio; CI: confidence interval; HGSC: high-grade serous carcinoma. Adjusted for age at diagnosis, region of residence, race/ethnicity, primary surgery, and stage.
N/A: HR could not be calculated because no deaths occurred during this time period.
a
Northeast includes Michigan, Iowa, New Jersey, and Connecticut; Northwest includes Washington and Alaska; Southeast includes Georgia, Kentucky, and Louisiana; Southwest includes California, Hawaii, New Mexico, and Utah.
b
HRs for American Indian/Alaskan Native not shown due to low numbers of cases and unstable estimates.
c
Models additionally adjusted for histotype (endometrioid, low-grade serous, clear cell and mucinous carcinoma).