TABLE 3.
Univariate and multivariate analysis of factors associated with locoregional recurrence in patients with locally advanced esophageal cancer treated with neoadjuvant chemoradiation followed by esophagectomy
| Variable | Univariate | Multivariate | ||
|---|---|---|---|---|
| Hazard ratio (95%CI) | P-value | Hazard ratio (95%CI) | P-value | |
| Lymphovascular invasion | 1.46 (0.97, 2.21) | 0.07 | ||
| Perineural invasion | 1.27 (0.82, 1.96) | 0.29 | ||
| Lymph node ratio (reference ≤0.2) | ||||
| 0.2 to 0.5 | 1.69 (0.97, 2.96) | 0.06 | ||
| >0.5 | 2.16 (1.32, 3.54) | 0.02 | ||
| Final T stage (reference T0) | ||||
| T1/2 | 1.50 (0.99, 2.28) | 0.06 | ||
| T3/4 | 2.06 (1.36, 3.11) | <0.01 | ||
| Positive margin | 1.95 (1.00,3.80) | 0.05 | 1.52 (0.75, 3.01) | 0.25 |
| Treatment response (reference complete response) | ||||
| Partial response | 1.80 (1.20, 2.70) | <0.01 | 1.69 (1.10, 2.59) | 0.02 |
| No response | 1.99 (1.21, 3.27) | <0.01 | 2.00 (1.19, 3.33) | <0.01 |
| Clinical uT stage (reference uT1/2) | ||||
| uT3/4 | 2.62 (1.33, 5.16) | <0.01 | 2.43 (1.24, 4.78) | <0.01 |