Table 2.
ESAS Scores According to Urinary THC Results
| Symptom | THC-Positive Group Median (LQ; UQ) |
THC-Negative Group Median (LQ; UQ) |
P Valuea | OR (95% CI) | P Valuea,b |
|---|---|---|---|---|---|
| Total, n (%) | 76 (22.9%) | 256 (77.1%) | |||
| Pain | 7 (5; 8) | 5 (3; 7) | .001 | 1.187 (1.066–1.323) | .002 |
| Fatigue | 4 (2; 6) | 6 (4; 8) | .290 | 1.076 (0.971–1.193) | .161 |
| Drowsiness | 1 (0; 3) | 3 (1; 6) | .152 | 1.067 (0.966–1.178) | .199 |
| Nausea | 1 (0; 3) | 0 (0; 3) | .049 | 1.105 (0.998–1.224) | .055 |
| Appetite | 4 (2; 7) | 3 (0; 5.75) | .015 | 1.130 (1.036–1.233) | .006 |
| Shortness of breath | 1 (0; 4) | 1 (0; 3) | .777 | 1.042 (0.942–1.151) | .425 |
| Depression | 3 (0; 6) | 2 (0; 5) | .544 | 1.071 (0.977–1.172) | .143 |
| Anxiety | 4 (1; 6) | 3 (1; 6) | .220 | 1.061 (0.969–1.160) | .199 |
| Overall well-being | 6 (4; 7) | 5 (3; 6) | .002 | 1.242 (1.096–1.407) | .001 |
| Spiritual well-being | 5 (2; 6) | 3 (1; 3) | .015 | 1.125 (1.027–1.231) | .011 |
| Constipation | 1 (0; 6) | 1 (0; 5) | .676 | 1.071 (0.993–1.166) | .117 |
| Insomnia | 7 (5; 9) | 4 (2; 7) | <.001 | 1.229 (1.118–1.350) | <.001 |
| Total ESAS | 52 (34; 66) | 44 (29; 54) | .001 | 1.027 (1.012–1.041) | <.001 |
Abbreviations: ESAS, Edmonton Symptom Assessment Scale; LQ, lower quartile; OR, odds ratio; THC, tetrahydrocannabinol; UQ, upper quartile.
a
Bold indicates statistically significant P values.
b
Multiple logistic regression for urinary THC results was adjusted for age, sex, and cancer type.