. Author manuscript; available in PMC: 2020 Dec 29.

Published in final edited form as: Int J Cancer. 2019 Feb 12;145(9):2342–2348. doi: 10.1002/ijc.32162

Table 2.

Fiber intake and the risk of head and neck cancer in the PLCO cohort.

			Head and Neck Cancer			Oral cavity and Pharynx				Larynx
Nutrients	Cohort	Cases	HR^*	95% CI	p -value	Cases	HR^*	95% CI	p -value	Cases	HR^*	95% CI	p -value
*Total fiber (g/day)*
Q1 (<13.56)	33,874	78	1.00	-	-	42	1.00	-	-	35	1.00	-	-
Q2 (≥13.56 to <20.00)	33,901	62	0.73	0.50–1.06	0.094	41	0.80	0.49–1.28	0.349	21	0.66	0.36–1.23	0.191
Q3 (≥20.00)	33,925	46	0.43	0.25–0.76	0.003	26	0.34	0.16–0.71	0.004	20	0.67	0.28–1.59	0.361
p_trend				0.004				0.007				0.294
*Insoluble fiber (g/day)*
Q1 (<8.85)	33,853	86	1.00	-	-	48	1.00	-	-	37	1.00	-	-
Q2 (≥8.85 to <13.18)	33,929	54	0.57	0.39–0.83	0.003	34	0.57	0.36–0.93	0.023	20	0.59	0.32–1.08	0.089
Q3 (≥13.18)	33,918	46	0.38	0.22–0.65	<0.001	27	0.31	0.15–0.62	0.001	19	0.57	0.24–1.32	0.189
p_trend				<0.001				0.001				0.138
*Soluble fiber (g/day)*
Q1 (<4.53)	33,785	75	1.00	-	-	42	1.00	-	-	32	1.00	-	-
Q2 (≥4.53 to <6.67)	33,996	63	0.75	0.51–1.09	0.132	41	0.75	0.47–1.22	0.247	22	0.78	0.42–1.46	0.443
Q3 (≥6.67)	33,919	48	0.44	0.25–0.79	0.006	26	0.29	0.14–0.62	0.001	22	0.87	0.36–2.13	0.761
p_trend				0.007				0.003				0.686

Abbreviations: HR, hazard ratio; CI, confidence interval.

Adjusted by age, sex, body mass index, education, race/ethnicity, pipe smoking status, cigar smoking status, cigarette smoking status, pack-year cigarette smoking, alcohol drinking status, alcohol drinking intensity, marital status, non-alcohol total energy, and total vegetable and fruit intake.