TABLE 1.

Cefiderocol MICs required to inhibit the growth of 90% of Gram-negative bacilli (MIC₉₀)^a

Organism(s)b	No. of isolates tested	MIC (μg/ml)
		Range	MIC90
Enterobacterales
Escherichia coli	5,139	≤0.002–8	0.5
Meropenem not-susceptible E. coli	72	0.015–4	2
Klebsiella pneumoniae	4,627	≤0.002–8	1
Meropenem not-susceptible K. pneumoniae	689	0.004–32	4
Klebsiella oxytoca	1,434	≤0.002–4	0.25
Meropenem not-susceptible K. oxytoca	31	0.03–4	1
Enterobacter cloacae	1,800	≤0.002–128	1
Klebsiella (formerly Enterobacter) aerogenes	1,017	≤0.002–8	0.5
Meropenem not-susceptible Enterobacter speciesc	159	0.06–32	8
Citrobacter freundii complex	931	≤0.002–8	0.5
Citrobacter koseri	517	0.008–8	0.5
Meropenem not-susceptible Citrobacter species	32	0.015–8	2
Serratia marcescens	2,382	≤0.002–32	0.5
Meropenem not-susceptible S. marcescens	38	0.015–4	2
Proteus mirabilis	819	≤0.002–>256	0.12
Proteus vulgaris	537	≤0.002–0.5	0.12
Providencia rettgeri	341	≤0.002–>256	0.12
Morganella morganii	697	≤0.002–8	0.25
Non-glucose-fermenting Gram-negative bacilli
Pseudomonas aeruginosa	4,942	≤0.002–8	0.5
MDR P. aeruginosa	262	0.002–32	2
Acinetobacter baumannii	2,896	≤0.002–>256	2
MDR A. baumannii	368	0.015–>256	8
Stenotrophomonas maltophilia	1,173	≤0.002–64	0.25
MDR S. maltophilia	218	0.015–>256	0.25

^aAdapted from reference 19.

^bThe not-susceptible category includes isolates that tested intermediate and resistant. MDR, multidrug resistant, i.e., resistant to meropenem, amikacin, and ciprofloxacin.

^cIncludes Klebsiella aerogenes.