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Generation of p-cresol by a gut microbial glycyl radical enzyme. (a) Oxidative metabolic pathway in Clostridia for L-tyrosine conversion to p-cresol via a 4-hydroxyphenylacetate intermediate. (b) Hetero-octameric structure of the glycyl radical enzyme 4-hydroxyphenylacetate decarboxylase (PDB accession code: 2YAJ) with the b-subunit shown in yellow and the g-subunit shown in dark green. Insets show the two iron– sulfur clusters harbored in the g-subunit.
