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Dose escalation
| Dose (mg/m2) | Increase from prior dose level |
Number of patients treated |
|---|---|---|
| 120 | – | 1 |
| 200 | 67% | 1 |
| 330 | 65% | 1 |
| 500 | 52% | 1 |
| 750 | 50% | 2a |
| 1050 | 40% | 1 |
| 1470 | 40% | 1 |
| 2060 | 40% | 6 |
One patient replaced due to disease progression on cycle 1 day 2 (new brain metastases)
