Table 3.
Toxicities attributed to GGTI-2418 occurring in at least two subjects or Grade ≥ 3
| Grade 1 | Grade 2 | Grade 3 | Grade 4 | |
|---|---|---|---|---|
| Nausea | 8 (57%) | 1 (7%) | ||
| Diarrhea | 2 (14%) | 2 (14%) | ||
| Fatigue | 4 (28%) | |||
| Pruritis | 1 (7%) | 2 (14%) | ||
| Neutropenia | 1 (7%) | 1 (7%) | ||
| Decreased appetite | 2 (14%) | |||
| Bilirubina | 1 (7%) | 1a (7%) | ||
| Elevated alkaline phosphatase | 1a (7%) | |||
| Elevated aspartate aminotransferase (AST) | 1 (7%) | 1a (7%) | ||
| Elevated alanine aminotransferase (ALT) | 2a (14%) |
a
Concurrent with malignant biliary obstruction due to disease progression