Table 5.
Pharmacokinetics of GGTI-2418
| Dose | AUC (μg × h/mL) |
Cmax (μg/mL) |
t½ (h) |
Vd (L) |
RAUC | ||||
|---|---|---|---|---|---|---|---|---|---|
| Cycle 1 Day 1 | Cycle 2 Day 4 | Cycle 1 Day 1 | Cycle 2 Day 4 | Cycle 1 Day 1 | Cycle 2 Day 4 | Cycle 1 Day 1 | Cycle 2 Day 4 | ||
| 120 | 2.6 | 2.5 | N/Aa | N/Aa | 1.2 | 1.0 | 157 | 133 | 1.0 |
| 200 | 15.2 | 21.9 | 18.5 | 26.8 | 1.1 | 1.4 | 40.4 | 36.1 | 1.4 |
| 330 | 16.0 | 16.2 | 17.8 | 19.0 | 1.2 | 1.3 | 75.8 | 56.0 | 1.0 |
| 500 | 36.3 | 23.0 | 56.1 | N/Aa | 1.0 | 1.1 | 42.8 | 70.6 | |
| 750 | 66.0 | 68.7 | 0.84 | 26.0 | |||||
| 750 | 126 | 186 | 93.7 | 117 | 1.1 | 1.1 | 18.3 | 12.2 | 1.5 |
| 1050 | 180 | 160 | 1.1 | 20.6 | |||||
| 1470 | 295 | 320 | 226 | 226 | 0.89 | 1.1 | 13.1 | 14.6 | 1.1 |
| 2060 | 462 | 209 | 0.99 | 12.8 | |||||
AUC area under the curve, Cmax maximal serum concentration, RAUC accumulation factor for area under the curve, t½ half-life, Vd volume of distribution
a
No end-of-infusion pharmacokinetic sample obtained; linear extrapolation applied and data excluded from summary analyses