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. Author manuscript; available in PMC: 2020 Dec 29.
Published in final edited form as: J Med Chem. 2017 Jan 3;60(1):157–169. doi: 10.1021/acs.jmedchem.6b00923

Figure 3.

Figure 3.

Compounds 1–4. For 1, the KD values for BRD9 and BRD7 were determined by isothermal titration calorimetry (ITC) studies and reported by the Structural Genomics Consortium (SGC, www.thesgc.org/). The IC50 values of 2 for BRD1 and TAF1 were determined by BROMOscan and also reported by the SGC. The biochemical Ki values of 3 and 4 for the β-catenin/BCL9 interaction were determined by the AlphaScreen assay.24,25 The cell-based IC50 values were determined using the MTs tetrazolium assay to monitor the inhibitory effects on growth of triple negative breast cancer MDA-MB-231 cells. Each set of data is expressed as mean ± standard deviation (SD) (n = 3).