Table 4.
Prospective randomized human clinical trials of adult patients (age ≥18 years) being treated for in-hospital cardiac arrest with cardiopulmonary resuscitation including chest compressions administered either with or without the assistance of a free-standing audiovisual feedback device (not linked to external monitor or automated external defibrillator)
| Device | Author (year), Citation | Methodology | Setting | Sample size | Population | Primary outcome and findings | Secondary outcomes and findings |
|---|---|---|---|---|---|---|---|
| Ambu CardioPump | Cohen (1993) | RCT | Inpatient | 62 | Adult patients in medical ICU, coronary care unit, cardiac-catheterization laboratory, and medical wards at 1 academic medical center | Improved sustained ROSC in the device group (62% vs. 30%; P<0.03). Improved survival for ≥24 h (45% vs. 9%; P<0.04) | No improvement in survival to hospital discharge (7% vs. 0%; P=NS). Improved neurological status (GCS) in device group (8.0±1.3 vs. 3.5±0.3; P<0.02) |
| Cardio First Angel™ | Goharani (2019) | RCT | ICU | 900 | Adult patients with cardiac arrest in a mixed med-surg ICU at 8 academic medical centers | Improved sustained ROSC in the device group (66.7% vs. 42.4%, P<0.001) | Improved survival to ICU discharge (59.8% vs. 33.6%) and survival to hospital discharge (54% vs. 28.4%, P<0.001) in the device group |
| Vahedian-Azimi (2016) | RCT | ICU | 80 | Adult patients with cardiac arrest in a mixed med-surg ICU at 4 academic medical centers | Improved sustained ROSC in device feedback group (72% vs. 35%; P=0.001) | Decrease in rib fractures (57% vs. 85%; P=0.02), but not sternum fractures (5% vs. 17%; P=0.15) | |
| Vahedian-Azimi (2020) | RCT | ICU | 22 | Adult patients with cardiac arrest in a mixed med-surg ICU at 4 academic medical centers | The incidence of ROSC was similar between groups (P=0.64) | Guideline adherence was improved in the intervention group (P=0.0005). No significant decrease in rib fractures (P=0.31) or sternum fractures (P=0.15) |
RCT: Randomized controlled trial; ICU: Intensive care unit; ROSC: Return of spontaneous circulation; GCS: Glasgow Coma Scale; NS: Nonsignificant