Table 1.

Morphological and molecular features of precancerous lesions of the gynecological tract.

Location	Precancerous lesion	Morphological features	Molecular features
Endometrium	EmGD	Some nuclear atypia, some nucleomegaly.	Low rates of loss of heterozygosity in TP53 and chromosome P1. p53 mutations in 50% of cells. Staining for P53, MIB1, and IMP3.
	EIC	Extensive nuclear atypia, extensive nucleomegaly, hyperchromasia.	High rates of loss of heterozygosity in TP53 and chromosome P1. p53 mutations in 75% of cells. Strong staining for P53, MIB1, and IMP3.
Fallopian tube	ESTP	No visible morphological features.	TP53 mutations, p53 staining, DNA damage.
	STIC	Hyperchromasia, nucleomegaly.	TP53 mutations, p53 and MIB1 staining, DNA damage, Chromosomal instability.