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. 2020 Dec 29;17(12):e1003467. doi: 10.1371/journal.pmed.1003467

Fig 1. Association of aortic stiffening with WM microstructure and CBF.

Fig 1

Higher aortic stiffening was associated with (A) higher RD, (B) higher AD, (C) lower FA, (D) higher MD, and (E) lower CBF. Associations with Phase 9 PWV, Phase 11 PWV, and ΔPWV are presented in pink, blue, and red yellow, respectively. Five horizontal slices are displayed with MNI152 coordinates ranging from Z = 65 to Z = 105 for WM and Z = 56 to Z = 104 for CBF. The WM clusters are overlaid on the study-specific mean FA skeleton (green) and the standard FMRIB58 FA image, and the CBF clusters are overlaid on the standard MNI152 brain. All results are thresholded at p < 0.05 (TFCE and FWE-corrected p-values) and are presented with a colour gradient for 1 p-values. AD, axial diffusivity; CBF, cerebral blood flow; FA, fractional anisotropy; FWE, family-wise error; L, left; MD, mean diffusivity; PWV, pulse wave velocity; R, right; RD, radial diffusivity; TFCE, threshold-free cluster enhancement; WM, white matter.