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. 2020 Dec 22;11(51):4754–4769. doi: 10.18632/oncotarget.27842

Figure 2. EPZ-6438 and PI-103 regulates the cell cycle progression and ROS generation.

Figure 2

(A) Cell cycle analysis was conducted to confirm the effect of EPZ and PI-103 on cell migration. Cells were arrested in G1 phase (85.7%) after the treatment with combination of drugs. (B) Cell apoptotic analysis was performed to get the insight into the effect of drug. DCFDA analysis showed the reduction of ROS in GBM U-87 cells. GBM U-87 cells have the high frequency of ROS at basal level. This data suggests that GBM U-87 cell progression is reduced after reduction in ROS. This data showed that cells are stuck in G1 phase but not going under apoptosis at this concentration.